General Medicine (ISSN:1311-1817)

The construction of new medicinal agents by molecular hybridization strategies is a powerful and emerging medicinal chemistry strategy to make novel medicinal agents with unique mechanisms of action through current discovery and development. Molecular hybridization is an important strategy in medicinal chemistry that can be effectively utilized to design multifunctional molecules through the combination of varied pharmacophores to obtain synergistic or additive effects. In this review, we analyze the synthesis and biological evaluation of a new class of hybrid Thio coumarin-chalcone derivative

The compound 4-amino-2-(2,3-dioxido-2H-thiopyran-5-yl)-4H-thiochromine-3,5,7-tris(oleate)sodium was isolated from garlic (Allium sativum) for its resistance to multidrug-resistant Acinetobacter baumannii. The garlic-derived compound was characterized using analytical physics techniques, specifically carbon-13 NMR and 1H-NMR spectroscopy, as well as GC-mass spectroscopy and FTIR to validate its structure. The bactericidal activity of various bacterial cells can be enhanced using pharmaceutical preparations that achieve physiological homeostasis by eliminating both pathogens and bacterial cells.

The current study investigates the factors predicting EI among women in Jordan. The study included 315 healthy women aged 18–45 years without ongoing health conditions. An assessment of sleep quality was performed using the Pittsburgh Sleep Quality Index (PSQI) while Trait Meta-Mood Scale (TMMS) was used to assess EI. Multiple linear regression reveals that, among all factors included in the model, only total sleep score (p<0.03), income (p<0.04), and education (p<0.04) are associated with EI. Furthermore, ANOVA revealed a significant effect of education level (P<0.001) for TMMS. An additio

Traditional medicine has been recognized as an important field of research in global healthcare, with increasing emphasis on evidence-based validation and standardization. Mongolia has a well-established tradition of utilizing herbal-based formulations as a means of disease prevention and treatment, with insomnia being one of the conditions commonly addressed. This investigation aimed to characterize the phytochemical composition and identify the bioactive compounds in "Lactuca," a recently developed, traditionally inspired herbal preparation. Phytochemical screening was carried out using thin

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