ANALYSIS OF COMPARISON OF KETAMINE AND SWEET-SEDATION (MIDAZOLAM) FOR PRE-MEDICATION IN PEDIATRIC ANESTHESIA

The study aims to analysis the comparison of ketamine and sweet-sedation (midazolam) for pre-medication in pediatric anesthesia. A study in Pakistan involving 120 patients aged two to eight years under general anesthesia for elective surgery was conducted over six months in 2024. Patients were divided into two groups (Group K and Group M) and received oral premedications of midazolam or ketamine combined with honey. After surgery, patients were monitored for heart rate, blood pressure, and respiration rate using SPSS 26 for data analysis. The midazolam group 33 (55%) children were calm and sleepy during separation from their parents where as it was 28(46.7%) with ketamine. Midazolam found to have better anxiolytic action than ketamine. 26(43.4%) children in ketamine group were calm & sleepy during venepuncture compared to 23(38.4%) children in midazolam group significantly. Ketamine had a superior degree of induction, excellent in 27(45%) children compared to 22(36.7%) with midazolam. So midazolam is significantly better. The prevalence of side impacts during post-operative side effects during the anesthesia time as well as preoperative side effects such as increased secretions, vomiting, nystagmus, and random limb movement in the ketamine groups contrasted to the midazolam group. The results seem to favor midazolam as the incidence of adjacent outcomes was higher with ketamine. Children can take ketamine (6 mg/kg) or midazolam (0.75 mg/kg) orally as premedicants. Midazolam, nevertheless, might be favored due to its rapid start of behavior, superior ability to reduce anxiousness throughout parent-child separation, and lower occurrence of adverse symptoms. The best option for an administration vehicle is honey because it is affordable, widely accessible, economical, readily absorbed, and well-liked by the pediatric population.