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[This article belongs to Volume - 26, Issue - 06]

ASSOCIATION BETWEEN HEPATIC STEATOSIS AND VITAMIN D INSUFFICIENCY IN NONALCOHOLIC FATTY LIVER DISEASE PATIENTS

The study aims to determine the association between hepatic steatosis and vitamin d insufficiency in nonalcoholic fatty liver disease patients. From August 2023 to February 2024, a descriptive study was carried out at the Department of Biochemistry in several locations in Bangladesh and Pakistan. The study was approved by the institution's ethical committee. This study included 108 NAFLD patients with a diagnosis and 100 chronologically and gender-matched controls. SPSS version 23.0 was used to conduct the statistical analysis. To identify the independent predictors of NAFLD, a logistic regression analysis was extended to incorporate possible components from the univariate analyses (a statistically significant value of <0.05 was employed). Laboratory values were demonstrated to rise in the Control group. Fasting blood glucose (FBG) revealed a significant p-value of 0.004, while vitamin D serum has a significant value (P-value 0.001). On the other hand, the p-value for ferritin, aspartate aminotransferase (AST), and uric acid was all 0.000. The levels of 25(OH)D were shown to be significantly correlated with HDL-C (p = 0.004), uric acid (p = 0.005), HbA1c (p = 0.002), the urine albumin/creatinine ratio (p = 0.001), FBG rates (0.031), and the erythrocyte sedimentation rate (ESR) (<0.001). Serum vitamin D levels were shown to be lower in NAFLD cases compared to controls. To assess additional evidence-based research, more investigations are required.