Evaluating Bcl-2 Expression In Submandibular Salivary Glands In Rabbits After Injection Of Biological Toxin.

Myoepithelial cells (MECs) are specialized cells of dual origin and have a unique mechanism of action and characteristics that distinguish them from other cells. They are essential for the secretion process by a mechanism that remains incompletely defined. The aim of this research was to investigate the expression and distribution of Bcl-2 protein in myoepithelial cells in the submandibular salivary gland after injecting biological toxin (in the context of drooling management), through an immunohistochemical study. A sample of 15 male rabbits was selected. 5 rabbits were a control sample (g1) and 10 rabbits had the biological poison injected into their salivary glands (g2). They were sacrificed, and the submandibular salivary gland was extracted and prepared for histological study. Sections taken from salivary glands showed clear cytoplasmic expression of Bcl-2 protein in myoepithelial cells In both groups. The expression was located around glandular acinar cells and ductal cells, P-value > 0.05 (there was no significant difference between the two groups). Myoepithelial cells have the property of resisting the process of programmed cell death, as a protein that inhibits this process (Bcl-2) was found in the cytoplasm of these cells in the submandibular salivary gland in healthy and paralyzed salivary glands in our research.