HIGH LEVEL OF MATERNAL PROGESTERONE IN EARLY SECOND TRIMESTER WITH PCOS AND its ROLE IN OBSTETRIC COMPLICATIONS: A COMPARATIVE STUDY

The purpose of this study was to assess the high level of maternal progesterone in early second trimester with PCOS and its role in obstetric complications. The comparative study was conducted in multi-settings of Pakistan during the period of 6 months (December 2023 to May 2024) after ethical approval of research. Simple random sampling was used to collect data. To get the data, simple random sampling was employed. Just 59 pregnant women with PCOS and 100 pregnant women without PCOS participated in the study. Participation in the study was open to all pregnant women aged ≥20. The study analyzed blood samples from pregnant women experiencing or not experiencing PCOS, focusing on prenatal and obstetric outcomes. The study evaluated anthropometric, metabolic, obstetric, and neonatal issues between women with and without PCOS. Regression analysis was performed. The age of PCOS-afflicted women was 32.7 ± 4.8 compared to non-PCOS 33.2 ± 6.1, and they were significantly more probable to have experienced a prior miscarriage history (37.3% versus 19.4%; P < 0.001). Preeclampsia was increasingly prevalent in PCOS-affected women than in non-PCOS-affected women (8.9% versus 1.7%; P = 0.000). Age, BMI, gestational weight gain, and blood pressure at the first or last prenatal consultation were not different across PCOS women with different hormone levels. Even after adjusting for age, comparable status, and preterm birth (adjusted OR 6.22, 95% CI 1.82 to 20.91), women with PCOS group still showed a higher probability of preeclampsia (OR 6.92, 95% CI 2.09 to 21.78). According to initial findings, preeclampsia was more common in women with PCOS who possessed the greatest maternal hormone levels in the first trimester of the second trimester.