Impacts of Vitamin B12 Supplements with Folic Acid and Iron on Hematological and Biochemical Markers during Pregnancy

Our study's objective was to examine how vitamin B12 supplements containing iron and folic acid affected haematological and biological indicators throughout pregnancy. The study involved 120 pregnant women from eight primary care practices, with 60 randomly assigned to either the intervention or control group. Biochemical and haematological measurements were performed at two intervals. Participants were required to have a healthy pregnancy, personal, familial, and obstetric history, and be aged 18-36. Blood samples were collected twice during pregnancy to determine the mother's blood group and tests for hepatitis B and immunization. There was a determination that the level of statistical significance was found to be P < 0.05. Both vitamin B-12 consumption and nutritional energy consumption were frequently low. A bare minimum of one-third of women were lacking in vitamin B-12 sufficiency several exhibited inadequate plasma levels of vitamin B-12, and almost thirty percent were anaemic at baseline. The three main haematological parameters—transferrin, UIBC, and TIBC—showed significantly greater elevations throughout the control and intervention groups as compared to the baseline. Values of those three parameters exceeded the reference range at the ultimate endpoint. Both the intervention and control groups' postintervention RBC and haptoglobin levels fell within the standard level. Additional information is provided underneath. The findings of this study lead the researchers to the conclusion that the pregnant women who took a vitamin B12 supplement saw favorable impacts on their haematological and biochemical indicators. According to the findings of this research, the administration of vitamin B12 during pregnancy has the potential to lessen the likelihood of the start of anaemia while still remaining within the acceptable range overall.