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[This article belongs to Volume - 26, Issue - 04]

Molecular evaluation of Mouse mammary tumor virus (MMTV) DNA level in blood cell and tumor tissue in prostate cancer

Prostate cancer is one of the most common malignancies in men, affecting both quality of life and life-threatening prognosis. Despite the recognized risk factors for prostate cancer, its etiology is generally little known, viruses could induce this tumor, notably the Mouse Mammary Tumor Virus (MMTV). In this study, our objective is to make a comparison between the presence of MMTV-type virus in the blood circulation and tissues of patients diagnosed with prostate cancer and their correlation with clinicopathological characteristics. Thus, we collected 50 blood samples from Moroccan patients, 50 tissues biopsies, and 50 control cases. Subsequently, we extracted viral DNA from these samples and amplified the target genes by real-time PCR for viral load quantification. Among the 50 tissue biopsies we detected 8/50 infected with MMTV, however, none of the blood samples was infected with MMTV and none of the control cases were infected. Data analysis allowed us to establish an association between the frequency of MMTV viral infection and some clinicopathological characteristics of patients. This work confirms previous research on the potential role of MMTV in the development of prostate cancer.