Relationship between Serum Lipid Derangements and Risk of Gastric Cancer

Our study aims to investigate the relationship between serum lipid derangements and risk of gastric cancer. A study was conducted at the Institute of Health Sciences of Pakistan's Ishrat Medical Facility in Gujranwala between January 2023 and November 2024 to assess the association between stomach cancer and serum lipid levels. 184 people with stomach cancer were screened, and a control group was created to exclude those with a history of diabetes, tumours, thyroid problems, persistent liver disease, or cholesterol-reducing drugs. Serologic positive for H. pylori IgG was determined using an immunoassay approach. The study used a two-sided two-sample t analysis to analyze continuous components and category variables. The statistical evaluation was performed using SPSS statistical software, edition 25.0. The average age of individuals with stomach cancer is 52 years, while those in a control group are 52. Individuals in the stomach cancer category were significantly more likely than those in the control group to have a family record of stomach malignancy (p<0.000) and to have H. pylori serum IgG positive (p<0.000) compared to the general population, males, and female groupings. According to the Cox-regression multivariate evaluation, smoke (risk ratio [HR], 4.283; p=0.002), advanced stage (p=0.0032), and hsCRP (p=0.002) all had a significant impact on the overall survival of patients with gastric cancer. In both the male and female groups, there had been no association among life expectancy and each of the elements of plasma lipids content. Less HDL-C (p=0.020), higher LDL-C (p=0.002), smoking status (p=0.01), a family record of stomach cancer (p<0.001), H. pylori IgG positivity (p<0.001), and advanced age (p<0.000) were all shown to be significantly associated with stomach malignancy in a multivariable investigation. In conclusion, serum lipid profiles are associated with the incidence of carcinoma of the stomach but not with its prognosis.