Results of Hepaclin-4, a traditional recipe-based in an experimental animal model of alcoholic liver disease and network pharmacology

Alcoholic liver disease (ALD) is a chronic liver disease caused by long-term heavy alcohol consumption. In recent years ethnomedicine has developed new pharmaceutical products based on traditional medicines. Hepaclin-4 (Hep-4) contains the plants that are used for different kinds of fever, as well as liver diseases: Scutellaria baicalensis Georgi, Saussurrea amara L, Chiazospermum erectum (L) Bernh, and Carthamus tinctorius L. This study, used literature and the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and chemical professional database, the Hep-4 and the single medicinal materials of prescriptions. The method for creating a pathological model of chronic alcoholic hepatitis was performed according to the method of researcher Fu Jian-feng (2006). The results show that the top 5 ingredients in terms of degree are: acacetin, quercetin, luteolin, baicalin, and pyrethrin. This indicates that Hep 4 significantly reduced liver transaminases in chronic alcoholic hepatitis. The severity of inflammation was estimated by the ratio of AST to ALT in the chronic alcoholic hepatitis. Acacetin, quercetin, luteolin, baicalin, and pyrethrin all show certain potential in the treatment of alcoholic liver disease, providing broad prospects for the development of new liver-protective drugs. Hep 4 demonstrated significant hepatoprotective efficacy, enhancing hepatic regeneration and mitigating cytolysis by reducing ALT, AST, CK-8, and CK-18 in experimental animals with chronic alcoholic hepatitis.