Three-Month Administration of FOLFOX Chemotherapy Regimen in Resectable Colorectal Cancer: A Mini Review

The combination of surgical resection and adjuvant chemotherapy is considered to be the most effective treatment for patients who have stage III colon cancer. FOLFOX, which stands for 5-fluorouracil and leucovorin (5FU/LV) and oxaliplatin, and CAPOX, which stands for capecitabine and oxaliplatin, were two of the recommended regimens for adjuvant chemotherapy administration. When deciding whether to administer adjuvant chemotherapy for a shorter or longer period of time, it is necessary to make a choice between the potential effects on survival and the potential for adverse effects and inconveniences. Studying this trade-off, which is a personal value judgement, can be accomplished by eliciting an individual's preferences for various options that are in competition with one another. Some patients will opt for adjuvant chemotherapy that is shorter and less toxic, but they will also run the risk of having a shorter survival time. On the other hand, other patients will opt for longer adjuvant chemotherapy, which comes with a higher risk of side effects, with the goal of maximising survival time. When making a decision regarding the length of adjuvant chemotherapy for patients with colon cancer, it is important to take into account not only the relevant data from the clinical condition, but also the specific characteristics, circumstances, and preferences of each individual patient.